全文获取类型
收费全文 | 6326篇 |
免费 | 688篇 |
国内免费 | 130篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 230篇 |
妇产科学 | 52篇 |
基础医学 | 719篇 |
口腔科学 | 94篇 |
临床医学 | 484篇 |
内科学 | 712篇 |
皮肤病学 | 33篇 |
神经病学 | 2041篇 |
特种医学 | 484篇 |
外科学 | 205篇 |
综合类 | 529篇 |
一般理论 | 1篇 |
预防医学 | 677篇 |
眼科学 | 40篇 |
药学 | 585篇 |
1篇 | |
中国医学 | 153篇 |
肿瘤学 | 71篇 |
出版年
2023年 | 129篇 |
2022年 | 149篇 |
2021年 | 331篇 |
2020年 | 290篇 |
2019年 | 310篇 |
2018年 | 297篇 |
2017年 | 326篇 |
2016年 | 323篇 |
2015年 | 318篇 |
2014年 | 464篇 |
2013年 | 495篇 |
2012年 | 423篇 |
2011年 | 473篇 |
2010年 | 316篇 |
2009年 | 311篇 |
2008年 | 329篇 |
2007年 | 270篇 |
2006年 | 231篇 |
2005年 | 191篇 |
2004年 | 135篇 |
2003年 | 120篇 |
2002年 | 108篇 |
2001年 | 75篇 |
2000年 | 53篇 |
1999年 | 51篇 |
1998年 | 43篇 |
1997年 | 46篇 |
1996年 | 34篇 |
1995年 | 31篇 |
1994年 | 34篇 |
1993年 | 33篇 |
1992年 | 34篇 |
1991年 | 31篇 |
1990年 | 14篇 |
1989年 | 23篇 |
1988年 | 11篇 |
1987年 | 12篇 |
1986年 | 12篇 |
1985年 | 26篇 |
1984年 | 37篇 |
1983年 | 30篇 |
1982年 | 32篇 |
1981年 | 19篇 |
1980年 | 27篇 |
1979年 | 12篇 |
1978年 | 18篇 |
1977年 | 8篇 |
1976年 | 20篇 |
1974年 | 8篇 |
1973年 | 10篇 |
排序方式: 共有7144条查询结果,搜索用时 93 毫秒
81.
Jill A. Poole Charles S. Barnes Jeffrey G. Demain Jonathan A. Bernstein Mahesh A. Padukudru William J. Sheehan Guillermo Guidos Fogelbach James Wedner Rosa Codina Estelle Levetin John R. Cohn Steve Kagen Jay M. Portnoy Andre E. Nel 《The Journal of allergy and clinical immunology》2019,143(5):1702-1710
82.
目的探讨白细胞(white blood cell,WBC)、红细胞(red blood cell,RBC)、血小板(platelet,PLT)、血红蛋白(hemoglobin,HB)、淋巴细胞绝对值(absolute lymphocyte value,Lym#)、平均血小板体积(mean platelet volume,MPV)与系统性红斑狼疮(systemic lupus erythematosus,SLE)病情活动性关系。方法随机收集2017年12月至2018年11月我院风湿免疫科SLE病人样本37例,根据SLE活动指数(systemic lupus erythematosus disease activity index,SLEDAI)分为活动组与非活动组,同时收集同期健康体检者22例作为对照组,检测样本的血常规相关指标Lym#、MPV、WBC、RBC、HB、PLT及血清补体3(serum complement 3,C3),红细胞沉降率(erythrocyte sedimentation rate,ESR),比较各指标之间的相关性。结果 SLE活动组与对照组比较,Lym#、C3、MPV、PLT、RBC、HB均小于对照组,差异具有统计学意义(P<0.05),两组间WBC无差异(P>0.05)。SLE非活动组与对照组间比较,Lym#、RBC、HB差异有统计学意义(P<0.05),二组间WBC、PLT、C3、MPV无差异(P>0.05)。SLE活动组与非活动组比较,活动组MPV、Lym#、C3、WBC、PLT、HB均低于非活动组,差异有统计学意义(P<0.05),ESR高于非活动组(P<0.05),两组间RBC无统计学差异(P>0.05)。WBC、RBC、HB、PLT、Lym#、MPV与SLE活动性指标SLEDAI、ESR呈负相关,与C3呈正相关。结论 WBC、RBC、HB、 PLT、Lym#、MPV可作为系统性红斑狼疮活动性的观察指标。 相似文献
83.
The effects of airborne particulate matter (PM) trace elements on health are widely concerned nowadays. Many achievements have been made while many unknowns exist. This article reports the recent research progresses, describes the effects of exposure to PM trace elements on health epidemiological evidence, toxicology findings, and raises some questions for future studies. 相似文献
84.
Lahbib Latrach Naaila Ouazzani Abdessamad Hejjaj Mustapha Mahi Tsugiyuki Masunaga Laila Mandi 《International journal of hygiene and environmental health》2018,221(1):64-80
This paper investigates the removal efficiency of organic matter, nitrogen, phosphorus, coliforms and pathogens from rural domestic wastewater in a two-stage vertical flow multi-soil-layering (MSL) system. The effects of wastewater quality, season and arid climate conditions on pollutants removal efficiency by the system were examined for one year. The experimental setup included two similar MSL systems composed of two layers: soil-mixture-layers (SML) and gravel permeable layers (PL) that are arranged in a brick like pattern. The applied hydraulic loading rate was 1000 L m?2 day?1. Results showed that most of the physicochemical contaminants elimination occurred while the wastewater percolated through the first MSL stage. The second stage demonstrated an improvement in the reduction of all pollutants, especially fecal bacteria indicators and pathogens. The mean overall removal rates performed by the two-stage MSL system were 97% for TSS, 96% for BOD5, 91% for COD, 96% for TN and 95% for TP. For bacterial indicators, the combination of two-stage MSL system achieved high log removals between 2.21 and 3.15 log units. Contaminants reduction processes in MSL technology are more dependent on internal than external environmental factors. The effectiveness of the two-stage MSL system to treat domestic wastewater was strongly influenced by wastewater quality. Significant relationships between influent contaminants level and their removal efficiency were found. The efficiency of MSL technology to reduce contaminants is not sensitive to season and air temperature fluctuations. This is due to the capacity of MSL system materials to withstand the air temperature variation, which highlights one of the advantages of MSL’s technology. Wastewater quality is the most important factor affecting the removal of contaminants in the MSL, which could be a critical parameter to considered when designing MSL system. Two-stage MSL system achieved a high treated wastewater quality amenable for treated wastewater reuse in agriculture recommended by Moroccan code of practice. Therefore, the combination of two-stage vertical flow MSL system could be considered an efficient and promising domestic wastewater treatment solution in arid countries to promote environmental protection and wastewater reuse. 相似文献
85.
Veronika Pilz Kathrin Wolf Susanne Breitner Regina Rückerl Wolfgang Koenig Wolfgang Rathmann Josef Cyrys Annette Peters Alexandra Schneider 《International journal of hygiene and environmental health》2018,221(3):510-518
Background
Long-term exposure to ambient air pollution contributes to the global burden of disease by particularly affecting cardiovascular (CV) causes of death. We investigated the association between particle number concentration (PNC), a marker for ultrafine particles, and other air pollutants and high sensitivity C-reactive protein (hs-CRP) as a potential link between air pollution and CV disease.Methods
We cross-sectionally analysed data from the second follow up (2013 and 2014) of the German KORA baseline survey which was conducted in 1999–2001. Residential long-term exposure to PNC and various other size fractions of particulate matter (PM10 with size of <10?μm in aerodynamic diameter, PMcoarse 2.5–10?μm or PM2.5?<?2.5?μm, respectively), soot (PM2.5abs: absorbance of PM2.5), nitrogen oxides (nitrogen dioxide NO2 or oxides NOx, respectively) and ozone (O3) were estimated by land-use regression models. Associations between annual air pollution concentrations and hs-CRP were modeled in 2252 participants using linear regression models adjusted for several confounders. Potential effect-modifiers were examined by interaction terms and two-pollutant models were calculated for pollutants with Spearman inter-correlation <0.70.Results
Single pollutant models for PNC, PM10, PMcoarse, PM2.5abs, NO2 and NOx showed positive but non-significant associations with hs-CRP. For PNC, an interquartile range (2000 particles/cm3) increase was associated with a 3.6% (95% CI: ?0.9%, 8.3%) increase in hs-CRP. A null association was found for PM2.5. Effect estimates were higher for women, non‐obese participants, for participants without diabetes and without a history of cardiovascular disease whereas ex-smokers showed lower estimates compared to smokers or non-smokers. For O3, the dose-response function suggested a non-linear relationship. In two-pollutant models, adjustment for PM2.5 strengthened the effect estimates for PNC and PM10 (6.3% increase per 2000 particles/cm3 [95% CI: 0.4%; 12.5%] and 7.3% per 16.5?μg/m3 [95% CI: 0.4%; 14.8%], respectively).Conclusion
This study adds to a scarce but growing body of literature showing associations between long-term exposure to ultrafine particles and hs-CRP, one of the most intensely studied blood biomarkers for cardiovascular health. Our results highlight the role of ultrafine particles within the complex mixture of ambient air pollution and their inflammatory potential. 相似文献86.
Milena Villarini Sara Levorato Tania Salvatori Elisabetta Ceretti Sara Bonetta Annalaura Carducci Tiziana Grassi Samuele Vannini Francesco Donato Silvia Bonetta Marco Verani Antonella de Donno Silvia Bonizzoni Alberto Bonetti Massimo Moretti Umberto Gelatti 《International journal of hygiene and environmental health》2018,221(6):883-892
Background
Recent data support the hypothesis that genetic damage occurring early in life during childhood can play an important role in the development of chronic diseases in adulthood, including cancer.Objectives
The objective of this paper, part of the MAPEC_LIFE project, is to describe the frequency of micronuclei and meta-nuclear alterations in exfoliated buccal cells of 6–8year-old Italian children recruited in five Italian towns (i.e., Brescia, Torino, Pisa, Perugia and Lecce) with different air pollution levels.Methods
About 200 children per town were recruited from primary schools. Biological samples were collected twice from the same children, in two different seasons (winter 2014-15 and late spring 2015). Cytogenetic damage was evaluated by the buccal micronucleus cytome assay.Results
Overall,n?=?1046 children represent the final cohort of the MAPEC_LIFE study. On the whole, the results showed a higher mean MN frequency in winter (0.42?±?0.54‰) than late-spring (0.22?±?0.34‰). MN frequency observed among the five Italian towns showed a trend that follows broadly the levels of air pollution in Italy: the highest MN frequency was observed in Brescia during both seasons, the lowest in Lecce (winter) and Perugia (late-spring).Conclusions
To the best of our knowledge, the number of recruited children included in the analysis (n?=?1046) is the highest compared to previous studies evaluating the frequency of MN in exfoliated buccal cells so far. MN frequency was associated with winter season and living in towns at various levels of air pollution, suggesting an important role of this exposure in determining early cytogenetic effects. 相似文献87.
88.
89.
OBJECTIVES: The aim of this study was to characterise the mineral density (MD) of natural enamel white spot lesions (WSLs) using X-ray micro-tomography calibrated with different density hydroxyapatite phantoms. METHODS: Seven natural WSLs from four extracted non-carious premolar teeth were scanned at a voxel size of 7.6 microm using a desktop X-ray micro-tomography system. Five hydroxyapatite phantoms (sintered pellets of hydroxyapatite powder) with densities ranging from 1.52 to 3.14 g/cm(3) were used as calibration standards for each scan. Three-dimensional image reconstruction enabled MD gradients throughout the lesion to be quantified using an MD calibration equation derived from hydroxyapatite phantoms. Background noise generated during the measurement of MD was reduced using a Gaussian filter. RESULTS: Gaussian filter reduced the signal-to-noise ratio (standard deviation) significantly while the basic MD information (average value) remained intact. The mineral gradients through the WSLs examined were compared and are discussed in terms of existing literature. The MD of sound enamel, apparent intact surface layer of WSL, and lowest level of WSL was found to be 2.65-2.89 g/cm(3), 2.23-2.58 g/cm(3) and 1.48-2.03 g/cm(3), respectively. Our MD results are comparable with other studies. CONCLUSIONS: X-ray micro-tomography is a sensitive in vitro technique capable of characterising and quantifying MD of small non-cavitated WSLs. This method has a promising potential for future carious and quantitative remineralisation studies. 相似文献
90.
Yuichi Kitasako Nathan J. Cochrane Matin Khairul Kanako Shida Geoffrey G. Adams Michael F. Burrow Eric C. Reynolds Junji Tagami 《Journal of dentistry》2010